PPARs in liver physiology

Peroxisome proliferator-activated receptors (PPARs) are nuclear and transcriptional modulators with crucial functions in hepatic whole-body energy homeostasis. Besides their well-documented roles lipid glucose metabolism, emerging evidence also implicate PPARs the control of other processes such as inflammatory responses. Recent technological advances, single-cell RNA sequencing, have allowed to unravel an unexpected complexity regulation PPAR expression, activity downstream signaling. Here we provide overview latest advances study liver physiology, a specific focus on formerly neglected aspects regulation, tissular zonation, cellular heterogeneity, circadian rhythms, sexual dimorphism species-specific features. • isotype expression is for distinct cell types. The spatially zonated across lobule. Hepatic PPARα PPARβ/δ display rhythmicity. presents dimorphism. PPAR-mediated gene some instances species-dependent.